Process for the preparation of D-(+)-biotin

US4732987A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Eike Poetsch · Mühltal, DE
• Michael Casutt · Pfungstadt, DE

Key dates

• Filing date: Apr 17, 1987
• Grant date: Mar 22, 1988
• Expiry date: Apr 17, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

D-(+)-Biotin can be prepared from optically active hydantoins of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given in patent claim 1, in a simple, stereospecific manner. Furthermore bicyclic nitriles of the formula XI ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given represent precious intermediate products and educts of a multitude of possibilities to synthesize optically active D-(+)-biotin.