Pharmaceutically useful carbostyril derivatives

US4734416A · kind A · utility

Assignee

• OTSUKA PHARMACEUTICAL CO., LTD.

Inventors

• Kazuo Banno · Tokushima, JP
• Takafuni Fujioka · Tokushima, JP
• Yasuo Oshiro · Tokushima, JP
• Kazuyuki Nakagawa

Key dates

• Filing date: Mar 28, 1979
• Grant date: Mar 29, 1988
• Expiry date: Mar 28, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Carbostyril derivatives having antihistamic action and central nervous controlling action are useful as antihistamic agents or central nervous controlling agents. The derivatives are represented by the general formula, ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 4 carbon atoms, an alkynyl group having 2 to 4 carbon atoms or a phenylalkyl group having an alkylene group containing 1 to 4 carbon atoms; R.sup.2 is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a phenyl group; R.sup.3 is a hydrogen atom, a hydroxy group, an alkyl group having 1 to 4 carbon atoms, an alkanolyoxy group having 1 to 4 carbon atoms or a 3,4,5-trimethoxybenzoyloxy group; R.sup.4 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R.sup.5 is a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group (which may have 1 to 3 substituted groups selected from the group consisting of halogen atoms, alkyl groups having 1 to 4 carbon atoms and alkoxy groups having 1 to 4 carbon atoms), an alkyl group having 1 to 4 carbon atoms (having one substituted group such as a hydroxy group, a phenyl group or an alkanoyloxy gr…