Chemorepellant compound
US4737413A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 30, 1986 |
| Grant date | Apr 12, 1988 |
| Priority date | — |
| Expiry date | Jun 30, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/31504
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A chemorepellant compound is disclosed having a general formula ##STR1## where R.sub.1 is H or an alkyl group in the range C.sub.1 to C.sub.6, and R.sub.2 is H or an appropriate hydroxyl protecting group, and pharmaceutically acceptable salts and esters thereof. A preferred form of the compound where R.sub.1 is hydrogen and R.sub.2 is hydrogen is made by incubating linoleic acid with soyabean lipoxygenase or with cytosol associated endothelial cell derived lipoxygenase. The chemorepellant compound can be bound to a prosthetic surface via an intermediate linking species such as a protein and studies have shown that platelet adhesion onto in the vicinity of a thrombogenic surface is greatly reduced in comparison to non-chemorepellant coated surfaces.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.