(2H)-3-benzazepin-2-ones, their pharmaceutical compositions and their pharmaceutical uses

US4737495A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Andreas Bomhard · Biberach, DE
• Manfred Psiorz · Ingelheim am Rhein, DE
• Joachim Heider · Warthausen, DE
• Norbert Hauel · Schemmerhofen, DE
• Klaus Noll · Cologne, DE
• Berthold Narr · Biberach, DE
• Walter Kobinger · Wien, AT
• Christian Lillie · Wien, AT

Key dates

• Filing date: May 30, 1986
• Grant date: Apr 12, 1988
• Expiry date: May 30, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new heteroaromatic amine derivatives of formula ##STR1## wherein A represents a --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--or ##STR2## group and B represents a methylene, carbonyl or thiocarbonyl group or A represents a --CO--CO or ##STR3## group and B represents a methylene group, in which the carbon atom marked x is linked to the phenyl nucleus, PA0 E represents a straight-chained alkylene group optionally substituted by an alkyl group, PA0 G represents a straight-chained alkylene group optionally substituted by an alkyl group, PA0 R.sub.1 represents a hydrogen, fluorine, chlorine or bromine atom, a trifluoromethyl, nitro, amino, alkylamino, dialkylamino, alkyl, alkylmercapto, hydroxy, alkoxy or phenylalkoxy group, PA0 R.sub.2 represents a hydrogen, chlorine or bromine atom or a hydroxy, alkoxy, phenylalkoxy or alkyl group or PA0 R.sub.1 and R.sub.2 together represent an alkylenedioxy group, PA0 R.sub.3 represents a hydrogen atom, an alkenyl group, an alkyl or phenylalkyl group, and PA0 Het represents a 5- or 6-membered heteroaromtic ring bonded via a carbon or nitrogen atom, which contains an oxygen, sulphur or nitrogen atom, two nitrogen atoms or a nitrogen…