.alpha..sub.2 -blocking derivatives of imidazole

US4738979A · kind A · utility

Assignee

• G.D. Searle LLC · US

Inventors

• Piedad Calderon · Brussels, BE
• Alexis Cordi · Suresnes, FR
• Claude L. Gillet · Ferrières, FR
• Hugo Gorissen · Grez-Doiceau, BE
• Georges E. Lambelin · Brussels, BE
• Joseph L. Roba · Wanlin, BE
• Michel P. Snyers · Limal, BE
• William R. Van Dorsser · Court-Saint-Etienne, BE

Key dates

• Filing date: Jan 27, 1986
• Grant date: Apr 19, 1988
• Expiry date: Jan 27, 2006

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of the formula: ##STR1## wherein X.sup.1, X.sup.2, Y.sup.1 and Y.sup.2, whether or not identical are hydrogen, a halogen such as fluoro, chloro or bromo, linear or branched alkyl of 1 to 3 carbon atoms, linear or branched alkoxy of 1 to 3 carbon atoms, carboxy, alkoxy-carbonyl of 1 to 3 carbon atoms or phenyl; PA0 R.sup.1 is hydrogen, methyl or phenyl; PA0 R.sup.2 and R.sup.3, which may or may not be identical, are hydrogen, hydroxyl, linear or branched alkyl of 1 to 6 carbon atoms, or linear or branched alkoxy group of 1 to 4 carbon atoms; PA0 R.sup.1 and R.sup.2 may together form a carbon-carbon double bond; and PA0 R.sup.4 and R.sup.5 whether or not identical, are hydrogen, linear or branched alkyl or 1 to 3 carbon atoms. The compounds are useful as blocking agents of .alpha..sub.2 -adrenergic receptors.