Process for the isolation of diaryl guanidines

US4739117A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Alfred Nierth · Leverkusen, DE
• Bernhard Scherhag · Leverkusen, DE
• Reinhard Preuss · Krefeld, DE
• Heinz Klose · Cologne, DE
• Salvatore Sabia · Cologne, DE

Key dates

• Filing date: Dec 16, 1986
• Grant date: Apr 19, 1988
• Expiry date: Dec 16, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C277/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Diaryl guanidines can be obtained in a high degree of purity and in high yields from the crude melt obtained from the reaction of arylamines and cyanogen chloride by dissolving the hot melt in water, extracting this solution with a mixture of at least one water insoluble, apolar hydrocarbon and at least one polar organic compound and precipitating the diaryl guanidine from the purified, aqueous solution by the addition of alkali metal hydroxide.