Preparation of biodegradable microspheres useful as carriers for macromolecules
US4741872A · kind A · utility
187Cited by
7References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 16, 1986 |
| Grant date | May 3, 1988 |
| Priority date | — |
| Expiry date | May 16, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2987
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.