Peptide antagonists of neurokinin B and opthalmic solutions containing them
US4742156A · kind A · utility
24Cited by
3References
10Claims
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Assignee
Inventor
Key dates
| Filing date | Aug 29, 1986 |
| Grant date | May 3, 1988 |
| Priority date | — |
| Expiry date | Aug 29, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Four decapeptides found to be analgesics and have antagonist activity to Neurokinin B which is also known as Neuromedin K. The decapeptide are of the following formula (I): EQU A.sup.1 -D-Pro.sup.2 His.sup.3 -D.sup.4 Phe.sup.5 D-Trp.sup.6 Val.sup.7 -D-Trp.sup.8 -Leu.sup.9 -Nle.sup.10 -NH.sub.2 (I) wherein A.sup.1 and D.sup.4 are Asp or D-Asp amino acids. Also described is an opthalmic solution to treat pain or inflammation and an HPLC separation method using piperidine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.