Process for the isomerization of asocainol

US4743686A · kind A · utility

Assignee

• Godecke Akt. · DE

Inventors

• Wolfram Geibel · Nettetal, DE
• Wolfgang Herrmann · Gothenburg, SE

Key dates

• Filing date: Nov 17, 1986
• Grant date: May 10, 1988
• Expiry date: Nov 17, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A new catalytic process for the isomerization of asocainol isomers at the 6-position which provides an inexpensive, rapid, and simple method for large scale production of the (R,R) isomer of (R,S) asocainol is asocainol. The (R,R) isomer of (R,S) asocainol is treated with small amounts of a salt and an oxidizing agent at an elevated temperature. The compounds and their pharmaceutically acceptable salts are useful as potent antiarrhythmic agents and local anesthetics.