N-(pyridinylalkyl)-thieno-or benzo-isothiazol-3-amine derivatives
US4743692A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 30, 1986 |
| Grant date | May 10, 1988 |
| Priority date | — |
| Expiry date | Sep 30, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D513/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of the formula: ##STR1## in which A is a 3,4-; 3,2-; or 2,3-fused thieno- moiety or a benzo- moiety; PA1 X is alkylene of 2 to 5 carbon atoms; PA1 R.sup.1 is hydrogen, bromo or methyl; PA1 R.sup.2 is methoxy when R.sup.1 is hydrogen, methyl when R.sup.1 is bromo, and bromo when R.sup.1 is methyl; PA1 R.sup.3 is hydrogen or alkyl of 1 to 6 carbon atoms; PA1 R.sup.4 is hydrogen or alkyl of 1 to 6 carbon atoms; PA1 R.sup.3 and R.sup.4, taken together, are ethylene when X is ethylene; PA1 R.sup.5 is hydrogen when A is thieno, and when A is benzo, R.sup.5 is hydrogen, alkyl of 1 to 6 carbon atoms, halo or alkoxy of 1 to 6 carbon atoms; PA1 R.sup.6 is hydrogen when A is thieno, and when A is benzo, R.sup.5 is hydrogen, alkyl of 1 to 6 carbon atoms, halo, alkoxy of 1 to 6 carbon atoms, amino, nitro, sulfamoyl or pyridinyl; PA1 m is one of the integers 0 or 1; PA1 n is one of the integers 3, 4 or 5; PA1 p is one of the integers 0, 1 or 2; and PA1 the dotted line in the thiazole ring represents unsaturation necessary to complete the 3,2- or 2,3- thieno- ring; or a pharmaceutically acceptable salt thereof are histamine H.sub.1 -antagonists useful in the treatment of various allerg…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.