Soluble and biodegradable polyamino acid activated for bonding of biologically active compound
US4745161A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 1, 1986 |
| Grant date | May 17, 1988 |
| Priority date | — |
| Expiry date | Apr 1, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G69/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention pertains to copolymers activated for bonding of biologically active compounds and to a method for preparation thereof. Soluble and biodegradable copolymers activated for bonding of biologically active compounds which have their main chain formed from units of aspartic acid or glutamic acid, or both, or also from units of other amino acids, according to the general formula I ##STR1## where n is 1 or 2, m is 1 or 2, a+b+c is 100, a is 0.5 to 100, b is 0 to 99.5, c is 0 to 80; the substituent R.sup.1 is --NH--NH.sub.2, --N.tbd.N or ##STR2## where x is 2 to 6, R.sup.2 is --NH(CH.sub.2).sub.x OH where x=2 to 6; and R.sup.3 is methyl, 2-propyl, 2-methylpropyl, butyl, 2-butyl, benzyl or 4-hydroxybenzyl, and the molecular weight is 5,000 to 1,000,000.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.