Solubilization of proteins for pharmaceutical compositions using heparin fragments
US4745180A · kind A · utility
62Cited by
6References
16Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 27, 1986 |
| Grant date | May 17, 1988 |
| Priority date | — |
| Expiry date | Jun 27, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/811
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is .beta.-interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated protein, which is poorly or not at all water-soluble at pH 6-8 without such solubilizing agent, is selectively conjugated to at least one heparin fragment having a terminal 2,5-anhydro-D-mannose residue which has an aldehyde not involved in intramolecular hemiacetal formation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.