Derivatives of 1,1,2,2-tetramethyl-1,2-bis-(2-fluoro-4-hydroxyphenyl)-ethane

US4745233A · kind A · utility

Assignee

• Asta-Werke Aktiengesellschaft · DE

Inventors

• Helmut Schonenberger · Pentling, DE
• Rolf Hartmann · Saarburg, DE
• Martin Schneider · Remchingen, DE
• Walter Schwarz · Pentling, DE
• Jurgen Engel · Alzenau, DE

Key dates

• Filing date: Jun 9, 1986
• Grant date: May 17, 1988
• Expiry date: Jun 9, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Antitumor compounds corresponding to the following formula: ##STR1## in which the substituents R.sub.1 and R.sub.2 may be the same or different and represent hydrogen, an aminocarbonyl group, a C.sub.1 -C.sub.6 alkylaminocarbonyl group, a di-C.sub.1 -C.sub.6 -alkylaminocarbonyl group, the group PO(OH).sub.2, a C.sub.2 -C.sub.8 alkanoyl group, a C.sub.2 -C.sub.8 halogen alkanoyl group or a C.sub.3 -C.sub.8 alkenoyl group, a process for their preparation, and their use in treating oestrogen-receptor-positive-tumors as well as the prostate carcinoma.