Method and device for metal-mirror cryofixation of biomedical or similar technical specimens
US4745764A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 27, 1987 |
| Grant date | May 24, 1988 |
| Priority date | — |
| Expiry date | Jul 27, 2007 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N1/42
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for metal-mirror cryofixation of bio-medical or similar technical specimens in which a specimen is brought into contact with a highly polished, cooled metal mirror in order to cool at least a marginal zone of the specimen suddenly to a low temperature. In order to avoid deformation of the specimen caused by freezing, provision is made, immediately after the first contact between the specimen and the metal mirror, to press the latter against one another by an additional independent force until the specimen is completely frozen. A cryofixation device for this purpose comprises a force generating device, for example, a separate power storage device (135) which, under control, functions after contact between the specimen (106) and metal mirror (102), in other words exerts the additional force between the specimen and the metal mirror (FIG. 7).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.