Tetrahydro-1,3-thiazin-2,4-dione derivatives

US4746738A · kind A · utility

Assignee

• Wella GmbH · DE

Inventors

• Wolfgang Hanefeld · Marburg, DE
• Rudi Rothlisberger · Marly, CH
• Friedrich Noser · Bonnefontaine, CH

Key dates

• Filing date: Mar 24, 1987
• Grant date: May 24, 1988
• Expiry date: Mar 24, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61Q19/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Skin treating composition on the basis of compatible carrier and additional compositions with a content of a defined tetrahydro-1,3-thiazine-2,4-dion derivatives as active ingredients for thickening the epidermis. The skin treating compositions are applied 1-2 times daily onto the skin for about 3 to 4 weeks. Due to the thickening of the epidermis they cause a reinforcmenet of the skin, in particular against sun rays, cold and the contact with noxious environmental substances of all kinds. Moreover, the skin treating compositions are suitable for a proplylactic fighting of the so-called old age skin. An object of the invention are novel tetrahydro-1,3-thiazine-2,4-dion derivative which are active in the aforementioned manner having the formula ##STR1## wherein R denotes H, alkyl, aryl, arylalkyl has substituted arylalkyl or substituted aryl in the aryl portion, R.sup.a =H is aryl or substituted aryl, R.sup.b =H, denotes aryl or substituted aryl and R.sup.c -H, represents alkyl or aryl, provided that R.sup.a, R.sup.b and R.sup.c only simultaneously denote H when R denotes a substituted arylalkyl in the aryl portion and R denotes H, but only if R.sup.a =HR.sup.b =aryl and R.sup.c con…