Pharmacologically active tripeptides and process for their synthesis
US4748155A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Mar 10, 1986 |
| Grant date | May 31, 1988 |
| Priority date | — |
| Expiry date | Mar 10, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0212
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmacologically active tripeptides, with at least a retro-inverted peptidic bond, definable by means of the following general formulae: ##STR1## their pharmaceutically acceptable salts, esters or alkyl amides, wherein PA0 R.sub.1 represents a hydrogen atom, an alkyl group with a maximum of 7 carbon atoms, an aryl, hydroxyalkyl or hydroxyarylalkyl, guanidylalkyl, amino-alkyl, alkyl-oxy-alkyl, acylamino-alkyl, imidazolylalkyl, indolyl-alkyl, mercapto alkyl, alkylmercaptoalkyl, carbamoyl-alkyl, carboxyalkyl, alkyl-carbamoylalkyl or alkyloxy-carbonylalkyl group; PA0 R.sub.2 represents a ##STR2## group, Z is an OH, OR.sub.3, NH.sub.2, NHR.sub.3 group, wherein PA1 R.sub.3 represents an alkyl group with a number of carbon atoms comprised within the range of from 1 to 10.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.