Thrombin-binding substance and process for preparing the same
US4748156A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 15, 1987 |
| Grant date | May 31, 1988 |
| Priority date | — |
| Expiry date | Jan 15, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K35/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel thrombin-binding substance having the characteristics of (a) molecular weight: 47,000.+-.6,000 in reduced condition and 38,000.+-.6,000 in unreduced condition, (b) isoelectric point: pH 4.9-5.7, (c) affinity: strong affinity to thrombin, (d) activity: (1) capable of promoting the thrombin catalyzed activation of protein C, (2) prolongs clotting time; and (e) stability: stable to denaturing agents (urea sodium and dodecylsulfate), can be prepared from a human placenta by means of extraction, fractionation using ion exchange chromatography and affinity chromatography, and/or gel filtration, followed by electrophoresis. The substance is useful as a medicine for the treatment of thrombosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.