"Physiologically-active novel substance ""Aldostatin"" and production method thereof"
US4749571A · kind A · utility
1Cited by
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2Claims
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Assignee
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Key dates
| Filing date | Feb 19, 1987 |
| Grant date | Jun 7, 1988 |
| Priority date | — |
| Expiry date | Feb 19, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/645
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A physiologically-active novel substance "aldostatin" having an estimated molecular formula of C.sub.20 H.sub.20 N.sub.2 O.sub.8 is produced by culturing an aldostatin-producing microorganism of the Pseudeurotium, for example, the Pseudeurotium zonatum M4109 strain. Aldostatin inhibits the aldose reductase activity and as a consequence, avoids abnormal accumulation of sorbitol, galactitol, etc. It is therefore effective for the treatment of chronic complications such as cataract, retinopathy and neuropathy caused by diabetes renalis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.