Renin inhibitors containing statine or derivatives thereof
US4749687A · kind A · utility
7Cited by
12References
49Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 10, 1986 |
| Grant date | Jun 7, 1988 |
| Priority date | — |
| Expiry date | Mar 10, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/86
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A series of novel peptide and polypeptide derivatives containing statine or derivatives thereof (e.g., aminostatine, cyclostatine) are disclosed that are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Of particular interest are compounds possessing the N-terminal sequence -Pro-Phe-His-Sta-Lys with the terminal proline nitrogen bonded to an amino-protecting acyl moiety or compounds possessing the N-terminal sequence -R-Phe-His-Sta-Lys- wherein R represents an amino protecting acyl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.