Antihypercholesterolemic beta-lactones
US4751237A · kind A · utility
9Cited by
3References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 28, 1986 |
| Grant date | Jun 14, 1988 |
| Priority date | — |
| Expiry date | Apr 28, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/365
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The compounds of the following general structural formula (I) ##STR1## wherein R is hydrogen or C.sub.1-3 alkyl and the tetrahydro analogs thereof, are 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would by useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.