Thrombin aerosol
US4752466A · kind A · utility
83Cited by
2References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 31, 1987 |
| Grant date | Jun 21, 1988 |
| Priority date | — |
| Expiry date | Aug 31, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process is disclosed for delivery thrombin in dry powdered form from an aerosol container by first lyophilizing an aqueous solution of thrombin and a thrombin-compatible synthetic polymer e.g. polyvinyl pyrrolidone, placing the lyophilized cake in a pressure bottle by crimping on a valve stem and top, filling liquified chlorofluoroalkane-containing aerosol propellant into the bottle, and actuating the valve to dispense in dry-finely divided powdered form a mixture of thrombin and polyvinyl pyrrolidone, which powdered thrombin is for use in controlling bleeding during surgery.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.