Sialylated Lewis.sup.x epitope, antibodies and diagnosis

US4752569A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Paul I. Terasaki · Los Angeles, US
• Masaki Hirota · Minamiuonuma, JP
• Kiyoyasu Fukushima · Gardena, US
• Akemi Wakisaka · Torrance, US
• Takashi Iguro · Torrance, US

Key dates

• Filing date: Jun 21, 1984
• Grant date: Jun 21, 1988
• Expiry date: Jun 21, 2004

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/808
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Detection of sialylated Lewis.sup.x antigen in sera is employed as diagnostic of the presence of cancer. Conveniently, monoclonal antibodies are provided which are shown to be useful in the diagnosis of a neoplastic condition, with a wide variety of different tumors. The hybridoma CSLEX1 was deposited at the A.T.C.C. on June 20, 1984 and given Accession No. HB8580.