Oxidation-resistant muteins
US4752585A · kind A · utility
40Cited by
3References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 5, 1986 |
| Grant date | Jun 21, 1988 |
| Priority date | — |
| Expiry date | Aug 5, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/142
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A biologically active reference therapeutic protein is protected against oxidation by a method involving substituting a conservative amino acid for each methionyl residue susceptible to chloramine T or peroxide oxidation, wherein additional, non-susceptible methionyl residues are not so substituted. The oxidation-resistant mutein so produced is preferably a human mutein of interleukin-2 or interferon-.beta., and the conservative amino acid is most preferably alanine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.