Modified tissue plasminogen activators
US4753879A · kind A · utility
34Cited by
12References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 27, 1984 |
| Grant date | Jun 28, 1988 |
| Priority date | — |
| Expiry date | Aug 27, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Modified human tissue plasminogen activators, the DNA sequences coding on expression for them and methods of making them in hosts transformed with those DNA sequences. The single chain form of these modified human t-PAs, t-PA (Lys 277.fwdarw.X), has a longer half life than the single chain form of native, or recombinant, t-PA, yet, in the two chain form these modified t-PAs have substantially the same affinity for fibrin and substantially the same activity as the two chain form of native, or recombinant, t-PA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.