Circulation-active substituted 1,4-dihydropyridine-3-carboxylic acid piperazides

US4753936A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Gerhard Franckowiak · Wuppertal, DE
• Gunther Thomas · Wuppertal, DE
• Matthias Schramm · Cologne, DE
• Michael Kayser · Hagen, DE
• Rainer Gross · Wuppertal, DE
• Martin Bechem · Wuppertal, DE

Key dates

• Filing date: Jan 12, 1987
• Grant date: Jun 28, 1988
• Expiry date: Jan 12, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

1,4-Dihydropyridine-3-carboxylic acid piperazides of the formula ##STR1## in which R.sup.1 is CN or alkyl, preferably methyl, PA0 R.sup.2 is H, CN, NO.sub.2 or preferably carboxyalkyl, PA0 R.sup.3 is aryl or heterocyclic, and PA0 R.sup.4 is alkyl, cycloalkyl, aryl or an acyl radical, and physiologically acceptable salts thereof, are circulation active. Novel intermediates are also provided.