Amides based on certain 1,8-naphtyridine-2-amines useful as anxiolytics
US4753941A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 13, 1987 |
| Grant date | Jun 28, 1988 |
| Priority date | — |
| Expiry date | Jan 13, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides new substituted amides of formula EQU R--CONH--Het in which: PA0 either R is phenyl substituted by acyloxy, alkylthio or alkyloxycarbonylamino, or by chloro at the 2- or 4-position, or by two alkyloxy radicals, or R is 2- or 4-pyridyl, pyrazinyl, 5,6-dihydrodithiin-2-yl, 5,6-dihydrooxathiin-2-yl, 1,3-dithiolyl, thiazolyl or substituted thienyl or furyl, or R is alkenyl (of 2 to 4 carbons) unsaturated in the .alpha.-position to the amide carbonyl, and Het is 1,8-naphthyridin-2-yl substituted at the 7-position by halogen, alkyloxy, phenoxy, 3-chloro- or dichlorophenoxy, hydroxy or cyano, PA0 or R is methoxyphenyl and Het is 1,8-naphthyridin-2-yl substituted in the 7-position by 3-chloro- or dichlorophenoxy, hydroxy or cyano, or R is methoxy-3-pyridazinyl and Het is 1,8-naphthyridin-2-yl substituted at the 7-position by phenoxy, the said alkyl and acyl radicals containing 1 to 4 carbon atoms in a linear or branched chain, their preparation and the pharmaceutical compositions which contain them. These new amides are useful as anxiolytics, hypnotics and muscle relaxants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.