Preparation of cephalosporins

US4754031A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Rolf Angerbauer · Wuppertal, DE
• Gunther Kinast · Wuppertal, DE

Key dates

• Filing date: May 6, 1985
• Grant date: Jun 28, 1988
• Expiry date: May 6, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D501/46
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of a cephalosporin of the formula ##STR1## in which R.sup.1 is an aliphatic or cycloaliphatic radical with up to 6 carbon atoms, and PA1 A is a pyridinium radical or a radical of the formula ##STR2## comprising reacting an acid of the formula ##STR3## with methanesulphonyl chloride to form an anhydride of the formula ##STR4## and reacting the anhydride with a 7-aminocephalosporanate of the formula ##STR5## The reaction proceeds smoothly and in high yield.