Carboline histamine H.sub.1 antagonists
US4754038A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 26, 1987 |
| Grant date | Jun 28, 1988 |
| Priority date | — |
| Expiry date | Feb 26, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Histaminic H.sub.1 -receptor antagonists of the formula: ##STR1## in which R.sup.1 is ##STR2## where R.sup.2 is hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, halo, nitro, cyano or trifluoromethyl; and R.sup.3 is hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, halo, nitro, cyano or trifluoromethyl; PA1 X is hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms or halo; PA1 Z is ##STR3## where R.sup.4 is pyridinyl, quinolinyl or benzoyl, any of which may be substituted by alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 3 carbon atoms, halo or trifluoromethyl; and m is one of the integers 2, 3 or 4; and PA1 n is one of the integers 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.