Klebsiella capsular polysaccharide vaccine
US4755381A · kind A · utility
20Cited by
2References
31Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 27, 1986 |
| Grant date | Jul 5, 1988 |
| Priority date | — |
| Expiry date | Mar 27, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/852
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to immunogenic preparations of Klebsiella species serotype-specific capsular polysaccharides. The invention involves the treatment of Klebsiella capsular polysaccharides in dilute sodium hydroxide to detoxify co-purified toxic lipopolysaccharides and to yield immunogenic vaccine preparations safe for parenteral administration to humans. The polyvalent vaccines prepared by use of the above vaccine are effective at providing protection against infections caused by Klebsiella species bacilli.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.