Spartein compounds, their preparation and use

US4755520A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Uwe Schon · Burgdorf, DE
• Wolfgang Kehrbach · Hannover, DE
• Bernd Hachmeister · Hannover, DE
• Gerd Buschmann · Velbert, DE
• Ulrich Kuhl · Gehrden, DE

Key dates

• Filing date: Jun 17, 1986
• Grant date: Jul 5, 1988
• Expiry date: Jun 17, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula (I) EQU S--(CH.sub.2).sub.n --A (I) in which PA1 S is a 17-spartein nucleus PA1 n is 0 or 1 PA1 and A is 2-furyl, 2-thienyl or 2-(N-alkyl)pyrryl when n=0, or 3-furyl or 3-thienyl when n=1, or pyridyl or a phenyl group of Formula (II) ##STR1## in which at least one of R.sub.1, R.sub.2 and R.sub.3 is a defined substituent other than hydrogen. Such compounds and corresponding compounds in which A is an unsubstituted phenyl group are useful in pharmaceutical compositions as heart affecting agents. Methods of preparing such compounds and pharmaceutical compositions are also disclosed.