3-oxadiazolyl-5-aminoalkyl-beta-carboline derivatives compositions and use

US4757070A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Helmut Biere · Berlin, DE
• Andreas Huth · Berlin, DE
• Dieter Rahtz · Berlin, DE
• Ralph Schmiechen · Berlin, DE
• Dieter Seidelmann · Berlin, DE
• David N. Stephens · Berlin, DE

Key dates

• Filing date: Dec 8, 1987
• Grant date: Jul 12, 1988
• Expiry date: Dec 8, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## wherein n is 0 or 1, PA0 R.sup.1 is hydrogen or lower alkyl, PA0 R.sup.2 and R.sup.3 each independently is hydrogen, optionally substituted lower alkyl, acyl or aryl, or together with the nitrogen atom form a 5-6-member heterocycle, PA0 R.sup.4 is hydrogen, lower alkyl or lower alkoxyalkyl and PA0 X is COOR.sup.6, CO--NR.sup.7 R.sup.8, or an oxadiazolyl radical of the formula ##STR2## wherein R.sup.5 is H, lower alkyl or cycloalkyl, PA0 R.sup.6 is H or lower alkyl, PA0 R.sup.7 and R.sup.8 each independently is hydrogen, optionally substituted lower alkyl, acyl or aryl, or PA0 R.sup.7 and R.sup.8 together with the nitrogen atom can form a 5-6-member heterocycle, are valuable drugs, e.g., have psychotropic activity.