2,5-diaryl tetrahydrothiophenes and analogs thereof as PAF-antagonists
US4757084A · kind A · utility
27Cited by
3References
9Claims
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Key dates
| Filing date | Sep 13, 1985 |
| Grant date | Jul 12, 1988 |
| Priority date | — |
| Expiry date | Sep 13, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Analogs of 2,5-Diaryl tetrahydrothiophenes which were substituted or unsubstituted on 3,4-positions were prepared. These compounds are found to be leukotriene inhibitors and potent and specific PAF (Platelet Activating Factor) antagonists. They are therefore useful in the treatment of various diseases or disorders mediated by the leukotriene and/or PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, adult respiratory distress syndrome, pain, and aggregation of platelets.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.