Gonadoliberin derivatives containing an aromatic aminocarboxylic acid in the 6-position, pharmaceutical and veterinary compositions containing them and process for preparing same
US4758552A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 2, 1987 |
| Grant date | Jul 19, 1988 |
| Priority date | — |
| Expiry date | Jan 2, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel gonadoliberin nonapeptide ethylamide or decapeptide amide derivatives of the general formula (I), EQU Glp-His-Trp-Ser-Tyr-X.sub.1 -X.sub.2 -X.sub.3 -Pro-X.sub.4 (I) wherein PA1 X.sub.1 stands for a 2-aminobenzoic or 3-aminobenzoic acid group; PA1 X.sub.2 stands for a leucyl, tryptophyl or phenylalanyl group; PA1 X.sub.3 means an arginyl, leucyl or glutaminyl group; and PA1 X.sub.4 represents a glycylamide or ethylamide group, as well as their acid addition salts and pharmaceutical presparations containing these compounds. Further on, the invention relates to a process for preparing these compounds and preparations. The gonadoliberin derivatives of the invention can more effectively be used for reproduction biological purposes as compared to the derivatives known so far.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.