(Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs
US4760057A · kind A · utility
116Cited by
4References
15Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 22, 1985 |
| Grant date | Jul 26, 1988 |
| Priority date | — |
| Expiry date | Apr 22, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to novel (acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs having a primary or secondary amine function thereon. Hydrolytic enzymes are used to trigger the regeneration of the parent amine drug of the carbamate prodrug moiety. The case also contains pharmaceutical composition, method of treatment and process claims.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.