Ether and ester derivatives of phenols
US4760061A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 24, 1985 |
| Grant date | Jul 26, 1988 |
| Priority date | — |
| Expiry date | Apr 24, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Mono- or bis-complex esters or ethers of a phenol derivative of the formula EQU NU--A--X--R.sup.1 wherein NU is a defined mono- or bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxyindanyl, hydroxyphenyl-hydroxybenzothienyl or di-hydroxyphenyl-ethylene or vinylene nucleus; wherein PA0 A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages, wherein PA0 R.sup.1 is hydrogen, or alkyl, alkenyl, cycloalkyl, halogenoalkyl, aryl or arylalkyl, or R.sup.1 is joined to R.sup.2, and wherein X is --CONR.sup.2 --, --CSNR.sup.2 --, --NR.sup.12 CO--, --NR.sup.12 CS--, --NR.sup.12 CONR.sup.2 --, ##STR1## --SO.sub.2 NR.sup.2 -- or --CO--, or, when R.sup.1 is not hydrogen, is --NR.sup.12 COO--, --S--, --SO-- or --SO.sub.2 --, wherein PA0 R.sup.2 is hydrogen or alkyl, or R.sup.1 and R.sup.2 together form alkylene; wherein PA0 R.sup.12 is hydrogen or alkyl, and wherein PA0 R.sup.22 is hydrogen, cyano or nitro; or a salt thereof when appropriate. The compounds possess antioestrogenic activity and may be used for the treatment of hormone-dependent breast tumours or of anovulatory infertility.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.