Process for producing .alpha.-L-aspartyl-L-phenylalanine methyl ester
US4760164A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 25, 1986 |
| Grant date | Jul 26, 1988 |
| Priority date | — |
| Expiry date | Feb 25, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0613
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for preparing an .alpha.-L-aspartyl-L-phenylalanine methyl ester which comprises the steps of reacting formyl-L-aspartic anhydride with L-phenylalanine in the presence of water at a high pH, to produce formyl-.alpha.-L-aspartyl-L-phenylalanine; removing the formyl group from the formyl-.alpha.-L-aspartyl-L-phenylalanine and esterifying the resultant compound with methanol and hydrogen chloride to produce the hydrogen chloride salt of .alpha.-L-aspartyl-L-phenylalanine methyl ester; neutralizing the hydrogen chloride salt of .alpha.-L-aspartyl-L-phenylalanine methyl ester; and filtering the neutralized solution to produce .alpha.-L-aspartyl-L-phenylalanine methyl ester.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.