Antagonists of specific excitatory amino acid neurotransmitter receptors having increased potency
US4761405A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 4, 1987 |
| Grant date | Aug 2, 1988 |
| Priority date | — |
| Expiry date | Mar 4, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4018
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention pertains to novel, potent anticonvulsants, analgesics, cognition enhancers and neuroprotectants achieving their action through the antagonism of specific excitatory amino acid neurotransmitter receptors. In particular, the invention is directed to .omega.-[2-(phosphonoalkylenyl)-cycloalkyl]-2-aminoalkanoic acids having general formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen, lower alkyl (C.sub.1 to C.sub.6), alkyl (C.sub.7 to C.sub.12), fatty acid chain (C.sub.13 to C.sub.24), aryl, aralkyl, hydroxyl; the stereoisomers being in their resolved or racemic form; n and m=0,1,2 or 3; z=0,1 or 2; the cycloalkyl ring being replaced with the cycloalkenyl ring; and the pharmaceutically acceptable salts and derivatives thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.