Antihypertensive dihydropyridine derivatives

US4761420A · kind A · utility

Assignee

• Laboratoires Syntex · FR

Inventor

• Gilles Genain · London, GB

Key dates

• Filing date: Jun 13, 1986
• Grant date: Aug 2, 1988
• Expiry date: Jun 13, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D309/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compound of formula 1 are calcium entry antagonists useful for treating hypertension, congestive heart failure, angina, and vasospastic disorders: ##STR1## wherein n is an integer from 1 to 4; PA0 R.sub.1 and R.sub.2 are lower alkyl; PA0 R.sub.3 is lower alkyl or alkoxyalkyl; PA0 A is alkylene of two to eight carbon atoms; PA0 X.sub.1 and X.sub.2 are each independently --NO.sub.2, --CF.sub.3, CH.sub.3 O--, --CN, --H, lower alkyl or halo; PA0 Y is --O--, --S--, --S(O)--, or --S(O).sub.2 --; and PA0 R is H, lower alkyl, cycloalkyl, alkoxyalkyl, cycloalkyloxy-alkyl, alkoxycycloalkyl, acyl, or saturated or unsaturated 5- or 6-membered heterocyclyl optionally substituted with lower alkyl or alkoxy, wherein the heteroatom is one oxygen atom.