Enkephalinase and endorphinase inhibitors as anti-craving compositions
US4761429A · kind A · utility
16Cited by
1References
8Claims
0Family size
Inventors
Key dates
| Filing date | Jul 22, 1985 |
| Grant date | Aug 2, 1988 |
| Priority date | — |
| Expiry date | Jul 22, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/19
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A new class of anti-craving compositions is provided by substances which inhibit breakdown of endogenous substances such as enkephalins and/or endorphins. An anti-alcohol craving effect is observed with an enkephalin breakdown inhibitor. Specifically, D-phenylalanine, DL-phenylalanine, D-leucine, DL-leucine, and hydrocinnamic acid, each an encephalin breakdown inhibitor, significantly lowered alcohol intake in animals and humans. The anti-alcohol desire effect is observed in animals genetically prone to choose alcohol over water solutions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.