Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
US4762823A · kind A · utility
18Cited by
6References
10Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 16, 1985 |
| Grant date | Aug 9, 1988 |
| Priority date | — |
| Expiry date | Oct 16, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for synthesizing monofluoromethyl- and difluoromethyluracil nucleosides from the corresponding thymine nucleosides is developed. These compounds which contain a partially fluorinated methyl group at the C-5 position (a new class of nucleosides) are potential antiviral and/or anticancer agents. The major features of the preparative route involve bromination of suitably protected thymine nucleosides followed by fluoride treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.