Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
US4764381A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 6, 1985 |
| Grant date | Aug 16, 1988 |
| Priority date | — |
| Expiry date | Dec 6, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the range of about 50% to 100% based on the weight of the carrier. The oleic acid may be used in combination with 2-ethyl-1, 3-hexanediol in an amount of about 1 to 40% based on the weight of the carrier to provide a synergistic effect with respect to percutaneous penetration enhancement. The compound 2-ethyl-1, 3-hexanediol as used alone and/or in combination with the oleic acid has been found to significantly enhance the delivery of a drug, to a patient, from a transdermal delivery system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.