Mixtures of optically active nitrodihydropyridines active on the circulatory system

US4764516A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Gerhard Franckowiak · Wuppertal, DE
• Rolf Grosser · Schwandorf, DE
• Gunter Thomas · Arese, IT
• Matthias Schramm · Cologne, DE
• Rainer Gross · Wuppertal, DE

Key dates

• Filing date: Dec 6, 1985
• Grant date: Aug 16, 1988
• Expiry date: Dec 6, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pure enantiomers of 5-nitrodihydropyridine of the formula ##STR1## are mixed, wherein one of the enantiomers has a high vasodilative action and a low negative inotropic activity on heart muscle, the other enantiomer has a low vasoconstrictive action and a high positive inotropic activity on heart muscle, the mixture being high in vasodilative activity and in positive inotropic activity on heart muscle.