2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine and a process for preparing same
US4764613A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 24, 1987 |
| Grant date | Aug 16, 1988 |
| Priority date | — |
| Expiry date | Aug 24, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the novel 2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine of the formula (I) ##STR1## as well as a process for the preparation of this compound, which is a useful intermediate in the preparation of the anti-atherosclerotic 2,6-bis(hydroxymethyl)pyridine bis(N-methylcarbamate) (pyridinolcarbamate) and other drugs. According to the invention, the compound of the formula (I) is prepared by reacting 2,6-bis(hydroxymethyl)pyridine of the formula (II) ##STR2## with chloromethyl chloroformate of the formula (III) ##STR3## in a polar-aprotic, water-immiscible organic solvent, in the presence of a basic substance between about -30.degree. C. and +10.degree. C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.