Stabilized liposome/amphotericin composition and method
US4766046A · kind A · utility
65Cited by
2References
4Claims
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Key dates
| Filing date | Sep 27, 1985 |
| Grant date | Aug 23, 1988 |
| Priority date | — |
| Expiry date | Sep 27, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/829
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A dehydrated liposome/amphotericin B composition which, upon addition of an aqueous medium, forms a suspension of liposomes (a) having a predetermined size distribution in size range less than about 1 micron, and (b) containing at least about 1 mole percent amphotericin B. The composition is prepared by forming a suspension of heterogeneous size amphotericin B liposomes in an aqueous solution containing at least about 0.5% of a membrane-stabilizing agent. The suspension is sized--for example, by extrusion through a small-pore polycarbonate membrane--to produce liposomes having the selected size distribution, and dehydrated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.