Recombinant DNA which codes for interleukin-1 B
US4766069A · kind A · utility
45Cited by
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24Claims
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Key dates
| Filing date | Jan 8, 1987 |
| Grant date | Aug 23, 1988 |
| Priority date | — |
| Expiry date | Jan 8, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/141
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically, the subject invention comprises the cloning of a cDNA synthesized by reverse transcription of poly(A)RNA isolated from adherent human monocytes stimulated with bacterial endotoxin. Human IL-1 is useful to induce the production of IL-2 by activated T-cells; it also acts on B-cells and NK-cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.