Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4766106A · kind A · utility
503Cited by
16References
15Claims
0Family size
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Key dates
| Filing date | Jan 25, 1988 |
| Grant date | Aug 23, 1988 |
| Priority date | — |
| Expiry date | Jan 25, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6827
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is .beta.-interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated protein, which is not water-soluble or not readily soluble in water at pH 6-8 without such solubilizing agent, is selectively conjugated to a water-soluble polymer selected from polyethylene glycol homopolymers or polyoxyethylated polyols.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.