Optionally 11- to 13-substituted ergoline compounds useful as medicinal agents

US4766128A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gerhard Sauer · Berlin, DE
• Gregor Haffer · Berlin, DE
• Helmut Wachtel · Berlin, DE
• Herbert Schneider · Berlin, DE
• Wolfgang Kehr

Key dates

• Filing date: Mar 14, 1984
• Grant date: Aug 23, 1988
• Expiry date: Mar 14, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted ergolines of the formula ##STR1## and their acid addition salts, wherein the urea side chain in the 8-position can be in the d.alpha.- or .beta.-configuration, C.sub.2 C.sub.3 and C.sub.9 C.sub.10 are a CC single or C.dbd.C double bond, and PA0 R is hydrogen or NR'R" wherein R'R" is O.sub.2, H.sub.2, C.sub.1-4 -dialkyl, or, together, they form a 3- to 9-membered ring, or R' and R" individually are hydrogen, C.sub.1-4 -alkyl, or C.sub.1-10- -acyl, PA0 R.sup.1 is hydrogen, C.sub.1-4 -alkyl, C.sub.1-10 -acyl, C.sub.6-8 -aryl, or C.sub.1-4 -alkylsulfonyl, PA0 R.sup.2 is hydrogen or halogen if C.sub.2 C.sub.3 is a C.dbd.C double bond, or hydrogen if C.sub.2 C.sub.3 is a CC single bond, PA0 R.sup.6 is C.sub.1-4 -alkyl, show a pronounced effect on the central nervous system and are suitable, for example, as antidepressants, neuroleptics, or antihypertensives.