Poly-4-aminopyrrole-2-carboxamido derivatives and their use as antiuiral or antitumor agents

US4766142A · kind A · utility

Assignee

• Farmitalia Carlo Erba S.r.l. · IT

Inventors

• Federico Arcamone · Milano, IT
• Nicola Mongelli · Milano, IT
• Sergio Penco · Milano, IT

Key dates

• Filing date: Oct 3, 1985
• Grant date: Aug 23, 1988
• Expiry date: Oct 3, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compound of the formula (I) ##STR1## wherein n is zero or an integer of 1 to 3; PA0 R is PA1 (a) --NHR.sub.3, wherein R.sub.3 is PA2 (a') --CON(NO)R.sub.4, in which R.sub.4 is C.sub.1 -C.sub.4 alkyl either unsubstituted or substituted by halogen; or PA2 (b') --CO(CH.sub.2).sub.m --R.sub.5, in which R.sub.5 is halogen, oxiranyl, methyloxiranyl, aziridinyl, a group ##STR2## or a group ##STR3## and m is zero or an integer of 1 to 4; or (b) ##STR4## wherein either R.sub.6 and R.sub.7 are the same and are each oxiranemethyl, aziridinemethyl, or C.sub.2 -C.sub.4 alkyl 2-substituted by halogen or by a group --OSO.sub.2 R.sub.8 wherein R.sub.8 is C.sub.1 -C.sub.4 alkyl or phenyl, or one of R.sub.6 and R.sub.7 is hydrogen and the other is as defined above; PA0 each group R.sub.1 is, independently, hydrogen or C.sub.1 -C.sub.4 alkyl; PA0 R.sub.2 is a C.sub.1 -C.sub.6 alkyl group terminating with (i) a basic moiety chosen from an amino group, a mono- or di- C.sub.1 -C.sub.6 alkylamino group, an amidino group, a group ##STR5## imidazolyl, imidazolinyl, tetrahydropyrimidinyl and oxazolidinyl; or (ii) a carboxy group; or (iii) a free hydroxy group --OH or a glycosilated hydroxy group --OD wherei…