Antihypertensive lactams

US4766210A · kind A · utility

Inventors

• John T. Suh · Greenwich, US
• Bruce E. Williams · Cottage Grove, US
• Jerry W. Skiles · Tuckahoe, US
• Bernard Loev · Scarsdale, US

Key dates

• Filing date: Jul 29, 1981
• Grant date: Aug 23, 1988
• Expiry date: Jul 29, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D281/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Antihypertensive compounds of the structure ##STR1## wherein: n is an integer from 0 to 2 inclusive, PA0 R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are independently hydrogen, alkyl having from 1 to 6 carbon atoms, alkenyl having from 2 to 6 carbon atoms, alkynyl having from 2 to 6 carbon atoms, cycloalkyl having from 3 to 16 carbon atoms, phenyl, benzyl, tolyl, naphthyl, phenethyl, indanyl, tetrahydronaphthyl, decahydronaphthyl, pyridyl, quinolyl, pyrrolidyl, pyrrolyl, morpholinyl, thiomorpholinyl, furyl, furfuryl, tetrahydrofurfuryl, benzimidazole, thienyl, imidolyl, or tetrahydroindolyl, and where the R.sub.1 to R.sub.7 groups are alkyl, said groups carrying a substituent selected from hydroxy, alkoxy, amino, carboxy, or carbalkoxy, the alkyl group in alkoxy and carbalkoxy having from 1 to 6 carbon atoms, or R.sub.2 taken together with R.sub.3 and the carbons to which they are attached is tetrahydronapthyl or phenyl, and when phenyl R.sub.1 and R.sub.4 are absent, or R.sub.6 and R.sub.7 taken together with the carbon to which R.sub.6 is attached and the nitrogen to which R.sub.7 is attached form a heterocycle selected from pyrrolidyl, thiazolidine, tetrahy…