Synthesis of tumor antigenic determinant
US4767845A · kind A · utility
8Cited by
2References
15Claims
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Key dates
| Filing date | Aug 17, 1987 |
| Grant date | Aug 30, 1988 |
| Priority date | — |
| Expiry date | Aug 17, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/6081
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Processes are provided for the synthesis of the human T-antigenic determinant 2-acetamido-2-deoxy-3-O-(.beta.-D-galactopyranosyl)-.alpha.-D-galactopyran oside containing an .alpha.-O-glycosidically linked bridging arm O--(CH.sub.2).sub.n COR. The determinant is coupled to carrier molecules to form artificial T-antigens, and to insoluble supports to form T-immunoadsorbents. The artifical T-antigen is shown to elicit a delayed type hypersensitivity reaction as a diagnostic for the presence of cancer in humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.